Article

T cell development is regulated by high fidelity replication of mitochondrial DNA

2022-12-20

Abstract excerpt

One of the most proliferative periods for T cells occurs during their development in the thymus. Increased DNA replication can result in increased DNA mutations in the nuclear genome, but also in mitochondrial genomes. A high frequency of mitochondrial DNA mutations can lead to abnormal mitochondrial function and have negative implications on human health. Furthermore, aging is accompanied by an increase in such m...

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Literature Corpus work: 29facafa-868b-531f-9626-b353629fc89f
DOI: 10.1101/2022.12.20.521061

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