Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The control of mitochondrial DNA replication during development and tumorigenesis.

Annals of the New York Academy of Sciences - 1 Sept 2015

Lee William T Y, St John Justin

Abstract excerpt

Mitochondrial DNA (mtDNA) copy number is strictly regulated during development and tumorigenesis. Pluripotent stem cells and cancer stem-like cells use glycolysis for energy metabolism, as they possess low mtDNA copy number, which promotes cell proliferation. As pluripotent stem cells can differentiate into all cell types of the body, they establish the mtDNA set point during early development, maintaining mtDNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to DNA-Directed DNA Polymerase
Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase gamma

Share to DNA Replication

Share to Embryonic Development

Share to Mitochondria

Share to Pluripotent Stem Cells

Source

Identifiers

PMID: 26335356
DOI: 10.1111/nyas.12873

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The control of mitochondrial DNA replication during development and tumorigenesis.PMID 26335356Read ↗

The role of the mtDNA set point in differentiation, development and tumorigenesis.Semantic proximity Read ↗

The regulation of mitochondrial DNA copy number in glioblastoma cellsSemantic proximity Read ↗

Mitochondrial genome alterations in cancer: From mutations and epigenetics to targeted therapiesack.Semantic proximity Read ↗

Human mitochondrial DNA replication machinery and disease.Semantic proximity Read ↗

No correlation between mtDNA amount and methylation levels at the CpG island of POLG exon 2 in wild-type and mutant human differentiated cells.Semantic proximity Read ↗

Homozygous c.820G>A variant in MGME1 contributes to multi-systemic mitochondrial dysfunction in an Indian patient cohortSemantic proximity Read ↗

Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects.Semantic proximity Read ↗

The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.Semantic proximity Read ↗

Mitochondrial genome undergoes de novo DNA methylation that protects mtDNA against oxidative damage during the peri-implantation windowSemantic proximity Read ↗

Changes in mitochondrial thymidine metabolism and mtDNA copy number during induced pluripotencySemantic proximity Read ↗

Mitochondrial activity in the regulation of stem cell self-renewal and differentiationSemantic proximity Read ↗

The significance of mitochondrial DNA changes during the onset and progression of head and neck squamous cell carcinoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.