Article

A genetic bottleneck of mitochondrial DNA during human lymphocyte development

2021-09-30

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondria are essential organelles in eukaryotic cells that provide critical support for energetic and metabolic homeostasis. Mutations that accumulate in mitochondrial DNA (mtDNA) in somatic cells have been implicated in cancer, degenerative diseases, and the aging process. However, the mechanisms used by somatic cells to maintain proper functions despite their mtDNA mutation load are poorly...

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Literature Corpus work: 3f7d13b6-9dda-5139-a744-bf2f5547e966
DOI: 10.1101/2021.09.28.462268

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