Article
Different faces of mitochondrial DNA mutators.
Biochimica et biophysica acta - 1 Nov 2015
Szczepanowska Karolina, Trifunovic Aleksandra
Abstract excerpt
A number of studies have shown that ageing is associated with increased amounts of mtDNA deletions and/or point mutations in a variety of species as diverse as Caenorhabditis elegans, Drosophila melanogaster, mice, rats, dogs, primates and humans. This detected vulnerability of mtDNA has led to the suggestion that the accumulation of somatic mtDNA mutations might arise from increased oxidative damage and could...
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