Article
Somatic mitochondrial DNA mutations in mammalian aging.
Annual review of biochemistry - 1 Jan 2010
Larsson Nils-Göran
Abstract excerpt
Mitochondrial dysfunction is heavily implicated in the multifactorial aging process. Aging humans have increased levels of somatic mtDNA mutations that tend to undergo clonal expansion to cause mosaic respiratory chain deficiency in various tissues, such as heart, brain, skeletal muscle, and gut. Genetic mouse models have shown that somatic mtDNA mutations and cell type-specific respiratory chain dysfunction can...
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