Article
Somatic cells with a heavy mitochondrial DNA mutational load render induced pluripotent stem cells with distinct differentiation defects.
Stem cells (Dayton, Ohio) - 1 May 2014
Wahlestedt Martin, Ameur Adam, Moraghebi Roksana, Norddahl Gudmundur L, Sten Gerd, Woods Niels-Bjarne, Bryder David
Abstract excerpt
It has become increasingly clear that several age-associated pathologies associate with mutations in the mitochondrial genome. Experimental modeling of such events has revealed that acquisition of mitochondrial DNA (mtDNA) damage can impair respiratory function and, as a consequence, can lead to widespread decline in cellular function. This includes premature aging syndromes. By taking advantage of a mutator...
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