Article

Editing of the Human TRIM5 Gene to Introduce Mutations with the Potential to Inhibit HIV-1

2017-09-06

Abstract excerpt

<h4>ABSTRACT</h4> The type I interferon (IFN-I)-inducible human restriction factor TRIM5α inhibits the infection of human cells by specific nonhuman retroviruses, such as N-MLV and EIAV, but does not generally target HIV-1. However, the introduction of two aminoacid substitutions, R332G and R355G, in the human TRIM5α (huTRIM5α) domain responsible for retroviral capsid recognition leads to efficient HIV-1 restrict...

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Literature Corpus work: 29b590c9-6737-5983-a4b4-db2124516471
DOI: 10.1101/185298

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