Article
Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1.
PloS one - 1 Jan 2018
Dufour Caroline, Claudel Alix, Joubarne Nicolas, Merindol Natacha, Maisonnet Tara, Masroori Nasser, Plourde Mélodie B, Berthoux Lionel
Abstract excerpt
The type I interferon (IFN-I)-inducible human restriction factor TRIM5α inhibits the infection of human cells by specific nonhuman retroviruses, such as N-MLV and EIAV, but does not generally target HIV-1. However, the introduction of two aminoacid substitutions, R332G and R355G, in the human TRIM5α (huTRIM5α) domain responsible for retroviral capsid recognition leads to efficient HIV-1 restriction upon stable...
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