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Article

Preclinical Assessment of Mutant Human TRIM5α as an Anti-HIV-1 Transgene.

Human gene therapy - 1 Oct 2015

Jung Ulrike, Urak Kevin, Veillette Maxime, Nepveu-Traversy Marie-Édith, Pham Quang Toan, Hamel Sophie, Rossi John J, Berthoux Lionel

Abstract excerpt

Current HIV-1 gene therapy approaches aim at stopping the viral life cycle at its earliest steps, such as entry or immediate postentry events. Among the most widely adopted strategies are CCR5 downregulation/knockout and the use of broadly neutralizing antibodies. However, the long-term efficacy and side effects are still unclear. TRIM5α is an interferon-stimulated restriction factor that can intercept incoming...

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Identifiers

PMID: 26076730
DOI: 10.1089/hum.2015.059
PMCID: PMC4630796

Genes

CCR5
TNF
TNFAIP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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