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Article

Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.

Journal of virology - 1 Mar 2006

Speelmon Emily C, Livingston-Rosanoff Devon, Li Shuying Sue, Vu Quyen, Bui John, Geraghty Daniel E, Zhao Lue Ping, McElrath M Juliana

Abstract excerpt

The innate antiviral factor TRIM5alpha restricts the replication of some retroviruses through its interaction with the viral capsid protein, leading to abortive infection. While overexpression of human TRIM5alpha results in modest restriction of human immunodeficiency virus type 1 (HIV-1), this i...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16474153
DOI: 10.1128/JVI.80.5.2463-2471.2006
PMCID: PMC1395369

Genes

TRIM5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16474153-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.PMID 16474153Read ↗

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