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Article

Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.

Journal of virology - 1 Mar 2006

Speelmon Emily C, Livingston-Rosanoff Devon, Li Shuying Sue, Vu Quyen, Bui John, Geraghty Daniel E, Zhao Lue Ping, McElrath M Juliana

Abstract excerpt

The innate antiviral factor TRIM5alpha restricts the replication of some retroviruses through its interaction with the viral capsid protein, leading to abortive infection. While overexpression of human TRIM5alpha results in modest restriction of human immunodeficiency virus type 1 (HIV-1), this inhibition is insufficient to block productive infection of human cells. We hypothesized that polymorphisms within TRIM5...

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Source

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Identifiers

PMID: 16474153
DOI: 10.1128/JVI.80.5.2463-2471.2006
PMCID: PMC1395369

Genes

TRIM5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.PMID 16474153Read ↗

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TRIM5 and the Regulation of HIV-1 InfectivitySemantic proximity Read ↗

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