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Article

A Single Amino Acid Change in the SPRY Domain of Human Trim5α Leads to HIV-1 Restriction

1 Jan 2005

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Share to Cytomegalovirus and herpesvirus research
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Share to Immune Cell Function and Interaction

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 15649369
DOI: 10.1016/j.cub.2004.12.042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A Single Amino Acid Change in the SPRY Domain of Human Trim5α Leads to HIV-1 RestrictionPMID 15649369Read ↗

Binding of the rhesus TRIM5α PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restrictionSemantic proximity Read ↗

Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and SpecificitySemantic proximity Read ↗

Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5αSemantic proximity Read ↗

High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans.Semantic proximity Read ↗

Retroviral restriction factor TRIM5alpha is a trimer.Semantic proximity Read ↗

Unique features of TRIM5α among closely related human TRIM family membersSemantic proximity Read ↗

Positive selection of primate <i>TRIM5</i> α identifies a critical species-specific retroviral restriction domainSemantic proximity Read ↗

Generation of human TRIM5alpha mutants with high HIV-1 restriction activity.Semantic proximity Read ↗

Editing of the human TRIM5 gene to introduce mutations with the potential to inhibit HIV-1.Semantic proximity Read ↗

Editing of the Human TRIM5 Gene to Introduce Mutations with the Potential to Inhibit HIV-1Semantic proximity Read ↗

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor FunctioningSemantic proximity Read ↗

Editing of the TRIM5 gene decreases the permissiveness of human T lymphocytic cells to HIV-1Semantic proximity Read ↗

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