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Article

Human Tripartite Motif 5α Domains Responsible for Retrovirus Restriction Activity and Specificity

1 Jul 2005

Abstract excerpt

The tripartite motif 5alpha protein (TRIM5alpha) is one of several factors expressed by mammalian cells that inhibit retrovirus replication. Human TRIM5alpha (huTRIM5alpha) inhibits infection by N-tropic murine leukemia virus (N-MLV) but is inactive against human immunodeficiency virus type 1 (HIV-1). However, we show that replacement of a small segment in the carboxy-terminal B30.2/SPRY domain of huTRIM5alpha...

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PMID: 15994791
DOI: 10.1128/jvi.79.14.8969-8978.2005

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