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Article

Interfering Residues Narrow the Spectrum of MLV Restriction by Human TRIM5α

20 Dec 2007

Abstract excerpt

TRIM5alpha is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5alpha-mediated MLV restriction. Our results reveal that changes at tyrosine(336) of human TRIM5alpha, within the variable region 1 of its C-terminal PRYSPRY domain, can expand its activity to B-MLV...

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PMID: 18166079
DOI: 10.1371/journal.ppat.0030200

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