Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor Functioning

19 Feb 2021

Abstract excerpt

Human immunodeficiency virus-1 (HIV-1) persists as a global health concern, with an incidence rate of approximately 2 million, and estimated global prevalence of over 35 million. Combination antiretroviral treatment is highly effective, but HIV-1 patients that have been treated still suffer from chronic inflammation and residual viral replication. It is therefore paramount to identify therapeutically efficacious...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytomegalovirus and herpesvirus research
Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33669846
DOI: 10.3390/v13020320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human TRIM5α: Autophagy Connects Cell-Intrinsic HIV-1 Restriction and Innate Immune Sensor FunctioningPMID 33669846Read ↗

A non-canonical role for the autophagy machinery in anti-retroviral signaling mediated by TRIM5αSemantic proximity Read ↗

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal DegradationSemantic proximity Read ↗

Interactomic analysis reveals a homeostatic role for the HIV restriction factor TRIM5α in mitophagySemantic proximity Read ↗

Anti-HIV Factors: Targeting Each Step of HIV's Replication CycleSemantic proximity Read ↗

The role of tripartite motif family members in mediating susceptibility to HIV-1 infectionSemantic proximity Read ↗

Restriction Factors: From Intrinsic Viral Restriction to Shaping Cellular Immunity Against HIV-1Semantic proximity Read ↗

TRIM Proteins and Their Roles in Antiviral Host DefensesSemantic proximity Read ↗

Friends and Foes: The Ambivalent Role of Autophagy in HIV-1 InfectionSemantic proximity Read ↗

TRIM5 and the Regulation of HIV-1 InfectivitySemantic proximity Read ↗

Canonical and Non-Canonical Autophagy in HIV-1 Replication CycleSemantic proximity Read ↗

TRIM5α Degradation via Autophagy Is Not Required for Retroviral RestrictionSemantic proximity Read ↗

The Antiviral Spectra of TRIM5α Orthologues and Human TRIM Family Proteins against Lentiviral ProductionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.