Article
Adaptation of HIV-1 to rhTrim5α-mediated restriction in vitro.
Virology - 1 Dec 2015
Setiawan Laurentia C, Kootstra Neeltje A
Abstract excerpt
Recently, gene therapy with rhTrim5α, an innate restriction factor which blocks HIV-1 at a post entry step, have been shown to be applicable as treatment in vitro. However, HIV-1 might adapt to replicate in the presence of rhTrim5α due to its high mutation rate. Here we observed that two different HIV-1 isolates were able to replicate in cells expressing high levels of rhTrim5α. Escape mutations were found in the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.