Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular evolution of the antiretroviral TRIM5 gene

23 Feb 2009

Abstract excerpt

In 2004, the first report of TRIM5alpha as a cellular antiretroviral factor triggered intense interest among virologists, particularly because some primate orthologs of TRIM5alpha have activity against HIV. Since that time, a complex and eventful evolutionary history of the TRIM5 locus has emerged. A review of the TRIM5 literature constitutes a veritable compendium of evolutionary phenomena, including elevated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Herpesvirus Infections and Treatments
Share to HIV Research and Treatment
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19238338
DOI: 10.1007/s00251-009-0358-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular evolution of the antiretroviral TRIM5 genePMID 19238338Read ↗

Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in MammalsSemantic proximity Read ↗

Genetic association of the antiviral restriction factor TRIM5alpha with human immunodeficiency virus type 1 infection.Semantic proximity Read ↗

TRIM5 and the Regulation of HIV-1 InfectivitySemantic proximity Read ↗

Identification of a Genomic Reservoir for New TRIM Genes in Primate GenomesSemantic proximity Read ↗

The role of tripartite motif family members in mediating susceptibility to HIV-1 infectionSemantic proximity Read ↗

Positive selection of primate <i>TRIM5</i> α identifies a critical species-specific retroviral restriction domainSemantic proximity Read ↗

Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha.Semantic proximity Read ↗

Long-term balancing selection maintains trans-specific polymorphisms in the human TRIM5 geneSemantic proximity Read ↗

The B30.2(SPRY) domain of the retroviral restriction factor TRIM5alpha exhibits lineage-specific length and sequence variation in primates.Semantic proximity Read ↗

Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection.Semantic proximity Read ↗

TRIM5α Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal DegradationSemantic proximity Read ↗

Evolution of a TRIM5-CypA splice isoform in old world monkeys.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.