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Amoxicillin-resistant <i>Streptococcus pneumoniae</i> can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

2021-09-13

Abstract excerpt

Antibiotic resistance in the important opportunistic human pathogen Streptococcus pneumoniae is on the rise. This is particularly problematic in the case of the β-lactam antibiotic amoxicillin, which is the first-line therapy. It is therefore crucial to uncover targets that would kill or resensitize amoxicillin-resistant pneumococci. To do so, we developed a genome-wide, single-cell based, gene silencing screen u...

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Literature Corpus work
29a35258-ef3d-5fe4-be0d-771864bc9c7c
DOI
10.1101/2021.09.13.460059
Open publication

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Amoxicillin-resistant <i>Streptococcus pneumoniae</i> can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seqDOI 10.1101/2021.09.13.460059
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