Article

A functional genetic landscape of antibiotic sensitivity across the pneumococcal pangenome reveals conserved and lineage-specific vulnerabilities

2026-02-26

Abstract excerpt

The large pangenome of Streptococcus pneumoniae enables this opportunistic pathogen to adapt and evade antibiotic treatment. Effective treatment of pneumococcal infections requires a better understanding of the genes that modulate susceptibility to antibiotics across the pangenome. Using CRISPRi-seq, we identified genes that contribute to antibiotic sensitivity against a panel of clinically relevant antibiotics a...

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Literature Corpus work: 59ee9df3-e603-51ff-8353-26c72af46a92
DOI: 10.64898/2026.02.26.708248

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