Article

Same same but different – The global response of <i>Escherichia coli</i> to five different LpxC inhibitors

2023-07-26

Abstract excerpt

A promising but yet clinically unexploited antibiotic target in difficult-to-treat Gram-negative bacteria is LpxC, the key enzyme in the biosynthesis of lipopolysaccharides (LPS), which are the major constituents of the outer membrane. To gain insights into the mode of action of five different LpxC inhibitors, we conducted a comparative phenotypic and proteomic analysis. All five compounds bound to purified LpxC f...

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Literature Corpus work: 53d7f8fb-ef76-5351-ac06-1a7f4210f690
DOI: 10.1101/2023.07.25.550486

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