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Dual CRISPRi-Seq for genome-wide genetic interaction studies identifies key genes involved in the pneumococcal cell cycle

2024-08-14

Abstract excerpt

A major goal in biology is to uncover the relationship between genotype and phenotype. However, identifying gene function is often hampered by genetic redundancy. For example, under standard laboratory conditions, three-quarters of the genes in the human pathogen Streptococcus pneumoniae are non-essential. A powerful approach to unravel genetic redundancy is by identifying gene-gene interactions. To uncover genet...

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Literature Corpus work: 9bb0cd6b-55db-5092-9284-c61662c8cb7e
DOI: 10.1101/2024.08.14.607739

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