Article

Full-length structure of the anti-viral and pro-tumor DNA deaminase APOBEC3B

2026-06-19

Abstract excerpt

Human APOBEC3B (A3B) restricts virus infections by catalyzing the deamination of cytosines to uracils in single-stranded DNA. A3B also contributes to mutagenesis and genome instability in cancer cells, driving tumor evolution and detrimental outcomes including therapy resistance and metastasis. A3B comprises tandem globular deaminase domains, with a multifunctional amino-terminal domain (NTD) and a catalytically a...

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Literature Corpus work: 4cd8a391-9a98-56c0-aa9b-556837336c21
DOI: 10.64898/2026.06.18.733170

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