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Article

Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.

PLoS genetics - 1 May 2018

Kasowitz Seth D, Ma Jun, Anderson Stephen J, Leu N Adrian, Xu Yang, Gregory Brian D, Schultz Richard M, Wang P Jeremy

Abstract excerpt

The N6-methyladenosine (m6A) modification is the most prevalent internal RNA modification in eukaryotes. The majority of m6A sites are found in the last exon and 3' UTRs. Here we show that the nuclear m6A reader YTHDC1 is essential for embryo viability and germline development in mouse. Specifically, YTHDC1 is required for spermatogonial development in males and for oocyte growth and maturation in females;...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29799838
DOI: 10.1371/journal.pgen.1007412
PMCID: PMC5991768

Genes

YTHDC1
CPSF6
SRSF3
SRSF7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development.PMID 29799838Read ↗

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