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Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation

28 Feb 2019

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a chronic and deadly disease with a poor prognosis and few treatment options. Pathological remodeling of the extracellular matrix (ECM) by myofibroblasts is a key factor that drives disease pathogenesis, although the underlying mechanisms remain unknown. Alternative polyadenylation (APA) has recently been shown to play a major role in cellular responses to stress by driving...

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PMID: 30830875
DOI: 10.1172/jci122106

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