Article

Molecular basis of neurodevelopmental disorder-causing mutation in nonsense-mediated mRNA decay factor UPF3B

2022-04-03

Abstract excerpt

<h4>ABSTRACT</h4> UPF3B is a key nonsense-mediated mRNA decay (NMD) factor required for surveillance of mRNA and regulation of eukaryotic gene expression. Mutations in UPF3B cause intellectual disability. The underlying molecular mechanisms remain unexplored as the mutations lie in an uncharacterized region of UPF3B. Here, we show that UPF3B shares structural and functional homology to the Drosophila Behavior/Hum...

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Literature Corpus work: d5767455-e8af-550a-9b3a-264fec904f50
DOI: 10.1101/2022.04.03.486873

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