Article

RNA matchmaking remodels lncRNA structure and promotes PRC2 activity

2020-04-14

Abstract excerpt

<h4>ABSTRACT</h4> Human Polycomb Repressive Complex 2 (PRC2) catalysis of histone H3 lysine 27 methylation at certain loci depends on long noncoding RNAs (lncRNAs). Yet, in apparent contradiction, RNA is a potent catalytic inhibitor of PRC2. Here we show that intermolecular RNA-RNA interactions between the lncRNA HOTAIR and its target genes can relieve RNA inhibition of PRC2. RNA matchmaking is promoted by hetero...

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Literature Corpus work: 28c208a2-900b-593e-9761-98d6979355ed
DOI: 10.1101/2020.04.13.040071

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