Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Long noncoding RNA as modular scaffold of histone modification complexes.

Science (New York, N.Y.) - 6 Aug 2010

Tsai Miao-Chih, Manor Ohad, Wan Yue, Mosammaparast Nima, Wang Jordon K, Lan Fei, Shi Yang, Segal Eran, Chang Howard Y

Abstract excerpt

Long intergenic noncoding RNAs (lincRNAs) regulate chromatin states and epigenetic inheritance. Here, we show that the lincRNA HOTAIR serves as a scaffold for at least two distinct histone modification complexes. A 5' domain of HOTAIR binds polycomb repressive complex 2 (PRC2), whereas a 3' domain of HOTAIR binds the LSD1/CoREST/REST complex. The ability to tether two distinct complexes enables RNA-mediated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromatin Immunoprecipitation
Share to Co-Repressor Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enhancer of Zeste Homolog 2 Protein

Share to Histone Demethylases

Share to Methylation

Share to Polycomb-Group Proteins

Share to Polycomb Repressive Complex 2

Share to RNA, Untranslated

Source

Open in PubMed Open full text

Identifiers

PMID: 20616235
DOI: 10.1126/science.1192002
PMCID: PMC2967777

Genes

REST

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Long noncoding RNA as modular scaffold of histone modification complexes.PMID 20616235Read ↗

Epigenomic footprints across 111 reference epigenomes reveal tissue-specific epigenetic regulation of lincRNAs.Semantic proximity Read ↗

RNA matchmaking remodels lncRNA structure and promotes PRC2 activitySemantic proximity Read ↗

Long noncoding RNA-mediated intrachromosomal interactions promote imprinting at the Kcnq1 locus.Semantic proximity Read ↗

Conserved architecture of a functional lncRNA-protein interaction in the DNA damage response pathwaySemantic proximity Read ↗

cis-Acting Complex-Trait-Associated lincRNA Expression Correlates with Modulation of Chromosomal Architecture.Semantic proximity Read ↗

Polycomb-mediated Genome Architecture Enables Long-range Spreading of H3K27 methylationSemantic proximity Read ↗

Structural and functional differences in the long non-coding RNA hotair in mouse and human.Semantic proximity Read ↗

Understanding the assembly and function of the CoREST co-repressor complexSemantic proximity Read ↗

A Comprehensive Characterization of the Function of LincRNAs in Transcriptional Regulation Through Long-Range Chromatin Interactions.Semantic proximity Read ↗

Polycomb Repressive Complex 2 Methylates Elongin A to Regulate Transcription.Semantic proximity Read ↗

The role of noncoding RNAs in chromatin regulation during differentiation.Semantic proximity Read ↗

Convergent evolution between PALI1 and JARID2 for the allosteric activation of PRC2Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.