Article

Regulation of histone methylation by automethylation of PRC2

2018-06-08

Abstract excerpt

<h4>ABSTRACT</h4> Polycomb Repressive Complex 2 (PRC2) is a histone methyltransferase whose function is critical for regulating transcriptional repression in many eukaryotes including humans. Its catalytic moiety EZH2 is responsible for the tri-methylation of H3K27 and also undergoes automethylation. Using mass spectroscopic analysis of recombinant human PRC2, we identified three methylated lysine residues (K510,...

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Literature Corpus work: efa30f15-5b4f-5d16-b8e8-0058aeadd942
DOI: 10.1101/343020

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