Article
Histone methylation by PRC2 is inhibited by active chromatin marks.
Molecular cell - 6 May 2011
Schmitges Frank W, Prusty Archana B, Faty Mahamadou, Stützer Alexandra, Lingaraju Gondichatnahalli M, Aiwazian Jonathan, Sack Ragna, Hess Daniel, Li Ling, Zhou Shaolian, Bunker Richard D, Wirth Urs, Bouwmeester Tewis, Bauer Andreas, Ly-Hartig Nga, Zhao Kehao, Chan Homan, Gu Justin, Gut Heinz, Fischle Wolfgang, Müller Jürg, Thomä Nicolas H
Abstract excerpt
The Polycomb repressive complex 2 (PRC2) confers transcriptional repression through histone H3 lysine 27 trimethylation (H3K27me3). Here, we examined how PRC2 is modulated by histone modifications associated with transcriptionally active chromatin. We provide the molecular basis of histone H3 N terminus recognition by the PRC2 Nurf55-Su(z)12 submodule. Binding of H3 is lost if lysine 4 in H3 is trimethylated. We...
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