Article
Huntingtin is an RNA binding protein and participates in NEAT1-mediated paraspeckles.
Science advances - 19 Jul 2024
Yadav Manisha, Harding Rachel J, Li Tiantian, Xu Xin, Gall-Duncan Terence, Khan Mahreen, Bardile Costanza Ferrari, Sequiera Glen L, Duan Shili, Chandrasekaran Renu, Pan Anni, Bu Jiachuan, Yamazaki Tomohiro, Hirose Tetsuro, Prinos Panagiotis, Tippett Lynette, Turner Clinton, Curtis Maurice A, Faull Richard L M, Pouladi Mahmoud A, Pearson Christopher E, He Housheng Hansen, Arrowsmith Cheryl H
Abstract excerpt
Huntingtin protein, mutated in Huntington's disease, is implicated in nucleic acid-mediated processes, yet the evidence for direct huntingtin-nucleic acid interaction is limited. Here, we show wild-type and mutant huntingtin copurify with nucleic acids, primarily RNA, and interact directly with G-rich RNAs in in vitro assays. Huntingtin RNA-immunoprecipitation sequencing from patient-derived fibroblasts and...
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