Article

Evaluation of the RNA-dependence of PRC2 binding to chromatin in human pluripotent stem cells

2023-08-18

Abstract excerpt

Polycomb Repressive Complex 2 (PRC2), an important histone modifier and epigenetic repressor, has been known to interact with RNA for almost two decades. In our previous publication (Long, Hwang et al. 2020), we presented data supporting the functional importance of RNA interaction in maintaining PRC2 occupancy on chromatin, using comprehensive approaches including an RNA-binding mutant of PRC2 and an rChIP-seq as...

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Literature Corpus work: 18c6215b-6145-5df1-bd46-379801f93826
DOI: 10.1101/2023.08.17.553776

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