Article

Denaturing purifications support direct interaction between PRC2 and RNA in cells

2026-05-22

Abstract excerpt

<h4>ABSTRACT</h4> Polycomb Repressive Complex 2 (PRC2) maintains repression of genes specific for other cell differentiation states. PRC2 binds RNA in vitro with a preference for G-rich sequences. UV-based crosslinking coupled with immunoprecipitation (CLIP) experiments have shown that PRC2 also binds RNA in cells. Recently, Guo et al reported that a stringent denaturing variant of CLIP called CLAP did not detect...

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Literature Corpus work: 78842456-aa07-588d-ad6d-8cb560b16056
DOI: 10.64898/2026.05.19.725914

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