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Large-scale genotyping and meta-analysis of <i>PIEZO1</i> short tandem repeat alleles suggest a modest association with malaria susceptibility

2024-06-13

Abstract excerpt

PIEZO1 forms a mechanosensitive ion channel involved in regulating calcium levels in red blood cells. E756del, a deletion allele within a short tandem repeat (STR) in PIEZO1 , is common in many African populations and has been proposed to be associated with protection from malarial disease, but epidemiological evidence has been inconsistent. Here, we use Illumina sequencing of amplicons covering the PIEZO1 STR t...

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Literature Corpus work
282d26ad-6ec9-558d-8b6a-2f36f7bc0676
DOI
10.1101/2024.06.12.598682
Open publication

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Large-scale genotyping and meta-analysis of <i>PIEZO1</i> short tandem repeat alleles suggest a modest association with malaria susceptibilityDOI 10.1101/2024.06.12.598682
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