Article

Common Piezo1 allele in African populations causes xerocytosis and attenuates Plasmodium infection

2017-07-06

Abstract excerpt

Hereditary xerocytosis (HX) is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. Gain-of-function (GOF) mutations in mechanosensitive Piezo1 ion channels are identified in HX patients. RBC dehydration is linked to reduced Plasmodium infection rates in vitro. We engineered a Piezo1 mouse model of HX and show that Plasmodium infection fails to cause exper...

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Literature Corpus work: ba3a0295-9ce4-5c01-b891-b6007d2ff933
DOI: 10.1101/159830

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