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Article

Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study.

Journal of human genetics - 1 Jan 2022

Thye Thorsten, Evans Jennifer A, Ruge Gerd, Loag Wibke, Ansong Daniel, Agbenyega Tsiri, Horstmann Rolf D, May Jürgen, Schuldt Kathrin

Abstract excerpt

Recently, a common genetic variant E756del in the human gene PIEZO1 was associated with protection from severe malaria. Here, we performed a genetic association study of this gain-of-function variant in a large case-control study including 4149 children from the Ashanti Region in Ghana, West Africa. The statistical analysis did not indicate an association with protection from severe malaria and, thus, providing...

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Identifiers

PMID: 34230590
DOI: 10.1038/s10038-021-00958-2
PMCID: PMC8727285

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Human genetic variant E756del in the ion channel PIEZO1 not associated with protection from severe malaria in a large Ghanaian study.PMID 34230590Read ↗

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