Genome-wide association study indicates two novel resistance loci for severe malaria.

doi:10.1038/nature11334

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Genome-wide association study indicates two novel resistance loci for severe malaria.

Nature - 20 Sept 2012

Timmann Christian, Thye Thorsten, Vens Maren, Evans Jennifer, May Jürgen, Ehmen Christa, Sievertsen Jürgen, Muntau Birgit, Ruge Gerd, Loag Wibke, Ansong Daniel, Antwi Sampson, Asafo-Adjei Emanuel, Nguah Samuel Blay, Kwakye Kingsley Osei, Akoto Alex Osei Yaw, Sylverken Justice, Brendel Michael, Schuldt Kathrin, Loley Christina, Franke Andre, Meyer Christian G, Agbenyega Tsiri, Ziegler Andreas, Horstmann Rolf D

Abstract excerpt

Malaria causes approximately one million fatalities per year, mostly among African children. Although highlighted by the strong protective effect of the sickle-cell trait, the full impact of human genetics on resistance to the disease remains largely unexplored. Genome-wide association (GWA) studies are designed to unravel relevant genetic variants comprehensively; however, in malaria, as in other infectious...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ABO Blood-Group System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Anemia, Sickle Cell

Share to Chromosomes, Human, Pair 1

Share to Chromosomes, Human, Pair 16

Share to Disease Resistance

Share to Ghana

Share to Malaria, Falciparum

Share to Plasma Membrane Calcium-Transporting ATPases

Source

Open in PubMed

Identifiers

PMID: 22895189
DOI: 10.1038/nature11334

Genes

MARVELD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide association study indicates two novel resistance loci for severe malaria.PMID 22895189Read ↗

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania.Semantic proximity Read ↗

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and OceaniaSemantic proximity Read ↗

Human genetics and malaria resistanceSemantic proximity Read ↗

A novel locus of resistance to severe malaria in a region of ancient balancing selection.Semantic proximity Read ↗

Functional analysis of genome-wide dataset from 17000 individuals identifies multiple candidate malaria resistance genes enriched in malaria pathogenic pathwaysSemantic proximity Read ↗

Reappraisal of known malaria resistance loci in a large multicenter study.Semantic proximity Read ↗

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospectsSemantic proximity Read ↗

Identification of ATP2B4 Regulatory Element Containing Functional Genetic Variants Associated with Severe Malaria.Semantic proximity Read ↗

Genome-Wide Association Studies of malaria susceptibility and resistance: progress, pitfalls and prospectsSemantic proximity Read ↗

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.Semantic proximity Read ↗

Genetic polymorphisms linked to susceptibility to malaria.Semantic proximity Read ↗

Genome-wide heritability analysis of severe malaria resistance reveals evidence of polygenic inheritance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.