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Article

A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humans

7 Apr 2020

Abstract excerpt

Significance The clinical presentation of Plasmodium falciparum malaria as severe versus uncomplicated is influenced by host genetic factors. Recently, a gain-of-function mutation in the mechanosensitive ion channel PIEZO1 was shown to protect mice against cerebral malaria, but its role in human malaria is unknown. Here we investigated a common PIEZO1 variant that encodes a mild gain-of-function mutant in human...

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PMID: 32265284
DOI: 10.1073/pnas.1919843117

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A common polymorphism in the mechanosensitive ion channel PIEZO1 is associated with protection from severe malaria in humansPMID 32265284Read ↗

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