Article
Common host variation drives malaria parasite fitness in healthy human red cells.
eLife - 23 Sept 2021
Ebel Emily R, Kuypers Frans A, Lin Carrie, Petrov Dmitri A, Egan Elizabeth S
Abstract excerpt
The replication of Plasmodium falciparum parasites within red blood cells (RBCs) causes severe disease in humans, especially in Africa. Deleterious alleles like hemoglobin S are well-known to confer strong resistance to malaria, but the effects of common RBC variation are largely undetermined. Here, we collected fresh blood samples from 121 healthy donors, most with African ancestry, and performed exome...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.