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Article

PIEZO1 variant implications for biological understanding and human health

1 Jul 2025

Abstract excerpt

The large membrane protein PIEZO1 assembles as trimers to form exceptional mechanical force-sensing ion channels of eukaryotes. When these channels are activated by force, cell membrane permeability to calcium ions and other ions increases rapidly, coupling force to cell function through ionic control. In humans and other species, PIEZO1 is both widely expressed and functional across major systems that include...

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PMID: 40628291
DOI: 10.1098/rsob.240345

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