Article

A common polymorphism in the druggable ion channel <i>PIEZO1</i> is associated with protection from severe malaria

2019-07-03

Abstract excerpt

Malaria caused by the Apicomplexan parasite Plasmodium falciparum has served as a strong evolutionary force throughout human history, selecting for red blood cell polymorphisms that confer innate protection against severe disease. Recently, gain-of-function mutations in the mechanosensitive ion channel PIEZO1 were shown to ameliorate Plasmodium parasite growth, blood-brain barrier dysfunction, and mortality in...

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Literature Corpus work: 20bbe487-4712-57d2-9c16-4948d59d2a50
DOI: 10.1101/691253

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