Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

doi:10.1016/j.cell.2018.02.047

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Article

Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection.

Cell - 5 Apr 2018

Ma Shang, Cahalan Stuart, LaMonte Gregory, Grubaugh Nathan D, Zeng Weizheng, Murthy Swetha E, Paytas Emma, Gamini Ramya, Lukacs Viktor, Whitwam Tess, Loud Meaghan, Lohia Rakhee, Berry Laurence, Khan Shahid M, Janse Chris J, Bandell Michael, Schmedt Christian, Wengelnik Kai, Su Andrew I, Honore Eric, Winzeler Elizabeth A, Andersen Kristian G, Patapoutian Ardem

Abstract excerpt

Hereditary xerocytosis is thought to be a rare genetic condition characterized by red blood cell (RBC) dehydration with mild hemolysis. RBC dehydration is linked to reduced Plasmodium infection in vitro; however, the role of RBC dehydration in protection against malaria in vivo is unknown. Most cases of hereditary xerocytosis are associated with gain-of-function mutations in PIEZO1, a mechanically activated ion...

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Identifiers

PMID: 29576450
DOI: 10.1016/j.cell.2018.02.047
PMCID: PMC5889333

Genes

PIEZO1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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