Article

Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion Formation

2025-06-21

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Atherothrombosis, the main event leading to acute coronary syndrome (ACS), is strongly linked to disturbed blood flow (d-flow) regions. Although the involvement of the Hippo pathway and its kinases Large Tumor Suppressor Kinase 1and 2 (LATS 1 and 2) in mechanical stress responses is known, the mechanisms by which d-flow simultaneously induces senescence, proliferation, and a...

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Literature Corpus work: 2828efd7-33ec-5764-8033-25d9b71e85fc
DOI: 10.1101/2025.06.19.660635

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Downregulation of LATS1/2 Drives Endothelial Senescence-Associated Stemness (SAS) and Atherothrombotic Lesion FormationDOI 10.1101/2025.06.19.660635Read

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