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EPAS1 Attenuates Atherosclerosis Initiation at Disturbed Flow Sites through Endothelial Fatty Acid Uptake

2023-12-08

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Atherosclerotic plaques form unevenly due to disturbed blood flow, causing localized endothelial cell (EC) dysfunction. Obesity exacerbates this process, but the underlying molecular mechanisms are unclear. The transcription factor EPAS1 (HIF2A) has regulatory roles in endothelium, but its involvement in atherosclerosis remains unexplored. This study investigates the potenti...

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Literature Corpus work
8cd8734c-6806-5adb-bf56-3a3bdba7563f
DOI
10.1101/2023.12.05.570309
Open publication

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