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Article

Glut1-dependent lactylation drives VSMC senescence phenotype.

Cellular signalling - 1 Jul 2026

Tang Yuming, Ouyang Jun, Mo Xifeng, Gan Yumei, Qin Naishen, Huang Mei, Wu Deping, Wei Shumin, Wu Haili, Huang Ziru, Qin Jiahui, Huang Jiangnan, Wang Hui

Abstract excerpt

Atherosclerosis (AS) is the leading cause of cardiovascular and cerebrovascular diseases. However, current clinical strategies to delay or treat AS are limited. Elucidating the underlying mechanisms of AS pathogenesis is critical for identifying novel therapeutic targets. Numerous studies have demonstrated that premature senescence of vascular smooth muscle cells (VSMCs) is a key contributor to AS progression,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41876049
DOI: 10.1016/j.cellsig.2026.112503

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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