Article

Senolytic treatment with fisetin reverses age-related endothelial dysfunction partially mediated by SASP factor CXCL12

2025-08-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Advancing age is the strongest risk factor for cardiovascular diseases (CVDs), primarily due to progressive vascular endothelial dysfunction. Cellular senescence and the senescence-associated secretory phenotype (SASP) contribute to age-related endothelial dysfunction by promoting mitochondrial oxidative stress and inflammation, which reduce nitric oxide (NO) bioavailability...

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Literature Corpus work: 1970ce16-c3fa-5417-89df-e23c36c95077
DOI: 10.1101/2025.08.13.670216

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