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Article

Twist1 Promotes Endothelial Phenotypic Transition and Unstable Plaque Phenotype During Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2026

Dy Danielle C M, Lehman Thiel, Henson Benjamin D, Shah Jeeya, Lin Jessica, Riascos Tiffany, Wirka Robert

Abstract excerpt

BACKGROUND: Comprehensive investigation of endothelial cell (EC) dysfunction during atherosclerosis with single-cell omics has resulted in the proposal that ECs undergo multiple alternative cell fate decisions during disease, but lack of lineage tracing or spatial localization complicates interpretation of these data. TWIST1, a causal gene for multiple atherosclerotic vascular diseases, is activated with low...

Read the complete abstract on PubMed

Topics

Animals
Twist-Related Protein 1
Plaque, Atherosclerotic
Humans
Atherosclerosis
Phenotype

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Endothelial Cells

Endothelial-Mesenchymal Transition

Mice

Nuclear Proteins

Mice, Knockout, ApoE

Disease Models, Animal

Male

Cells, Cultured

Mice, Inbred C57BL

Diet, High-Fat

Mice, Knockout

Source

Open in PubMed Open full text

Identifiers

PMID: 42689320
DOI: 10.1161/ATVBAHA.126.324428
PMCID: PMC13544331

Genes

TWIST1
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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