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Article

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy.

Science translational medicine - 26 Oct 2016

Oubaha Malika, Miloudi Khalil, Dejda Agnieszka, Guber Vera, Mawambo Gaëlle, Germain Marie-Anne, Bourdel Guillaume, Popovic Natalija, Rezende Flavio A, Kaufman Randal J, Mallette Frédérick A, Sapieha Przemyslaw

Abstract excerpt

Pathological angiogenesis is the hallmark of diseases such as cancer and retinopathies. Although tissue hypoxia and inflammation are recognized as central drivers of vessel growth, relatively little is known about the process that bridges the two. In a mouse model of ischemic retinopathy, we found that hypoxic regions of the retina showed only modest rates of apoptosis despite severely compromised metabolic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 27797960
DOI: 10.1126/scitranslmed.aaf9440

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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