Article
A novel role for cystathionine γ lyase in the control of p53: impact on endothelial senescence and metabolic reprograming
2022-09-05
Abstract excerpt
<h4>Aims</h4> Advanced age is unequivocally linked to the development of cardiovascular disease, however, the mechanisms leading to loss of endothelial cell regenerative capacity during aging remain poorly understood. Here we aimed to investigate novel mechanisms involved in endothelial cell senescence, that impact on endothelial cell transcription and the vascular repair response upon injury <h4>Methods and resu...
Topics
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- Antioxidant Activity and Oxidative Stress
- Atherosclerosis and Cardiovascular Diseases
- Cerebrovascular and Carotid Artery Diseases
- Cerebrovascular and genetic disorders
- Genetics, Aging, and Longevity in Model Organisms
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nitric Oxide and Endothelin Effects
- Telomeres, Telomerase, and Senescence
Identifiers and source
- Literature Corpus work
- 2857b868-6d35-5474-80a3-492c78380ffb
- DOI
- 10.1101/2022.09.05.506654
