Article
Localising loci underlying complex trait variation using Regional Genomic Relationship Mapping.
PloS one - 1 Jan 2012
Nagamine Yoshitaka, Pong-Wong Ricardo, Navarro Pau, Vitart Veronique, Hayward Caroline, Rudan Igor, Campbell Harry, Wilson James, Wild Sarah, Hicks Andrew A, Pramstaller Peter P, Hastie Nicholas, Wright Alan F, Haley Chris S
Abstract excerpt
The limited proportion of complex trait variance identified in genome-wide association studies may reflect the limited power of single SNP analyses to detect either rare causative alleles or those of small effect. Motivated by studies that demonstrate that loci contributing to trait variation may contain a number of different alleles, we have developed an analytical approach termed Regional Genomic Relationship...
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