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Article

Localizing Components of Shared Transethnic Genetic Architecture of Complex Traits from GWAS Summary Data.

American journal of human genetics - 4 Jun 2020

Shi Huwenbo, Burch Kathryn S, Johnson Ruth, Freund Malika K, Kichaev Gleb, Mancuso Nicholas, Manuel Astrid M, Dong Natalie, Pasaniuc Bogdan

Abstract excerpt

Despite strong transethnic genetic correlations reported in the literature for many complex traits, the non-transferability of polygenic risk scores across populations suggests the presence of population-specific components of genetic architecture. We propose an approach that models GWAS summary data for one trait in two populations to estimate genome-wide proportions of population-specific/shared causal SNPs. In...

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PMID: 32442408
DOI: 10.1016/j.ajhg.2020.04.012
PMCID: PMC7273527

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