Article

Principled measures and estimates of trait polygenicity

2025-07-15

Abstract excerpt

The ‘polygenicity’ of traits is often invoked and sometimes quantified in quantitative, statistical, and human genetics. What do we mean by the polygenicity of a trait? We propose a principled definition that encompasses a range of polygenicity measures. We show that these measures satisfy certain mathematical properties, we argue that these properties are sensible if not necessary, and we show that, conversely, m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 76ca7285-a36c-505a-a975-dd120c312b07
DOI: 10.1101/2025.07.10.664154

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Principled measures and estimates of trait polygenicityDOI 10.1101/2025.07.10.664154Read

Principled measures and estimates of trait polygenicity.Semantic proximity Read

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture ModelSemantic proximity Read

Beyond SNP Heritability: Polygenicity and Discoverability of Phenotypes Estimated with a Univariate Gaussian Mixture ModelSemantic proximity Read

A guide to performing Polygenic Risk Score analysesSemantic proximity Read

A Bayesian method for estimating gene-level polygenicity under the framework of transcriptome-wide association study.Semantic proximity Read

Beyond SNP heritability: Polygenicity and discoverability of phenotypes estimated with a univariate Gaussian mixture model.Semantic proximity Read

A scalable method for estimating the regional polygenicity of complex traitsSemantic proximity Read

Estimation of regional polygenicity from GWAS provides insights into the genetic architecture of complex traits.Semantic proximity Read

SNP-based heritability and selection analyses: Improved models and new results.Semantic proximity Read

Polygenic inheritance, GWAS, polygenic risk scores, and the search for functional variants.Semantic proximity Read

Methods for Polygenic Traits.Semantic proximity Read

Tutorial: a guide to performing polygenic risk score analyses.Semantic proximity Read